AUTOANTIBODIES TO THE MYELIN BASIC PROTEIN IN PATIENTS WITH SCHIZOPHRENIA HAVE PROTEOLYTIC ACTIVITY
- 作者: Parshukova D.A.1, Buneva V.N.2, Kornetova E.G.1, Kazantseva D.V.3, Vasilevа A.R.3, Ivanova S.A.1, Smirnova L.P.1
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隶属关系:
- Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
- Siberian Division of Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine
- Siberian State Medical University
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 451-454
- 栏目: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/120255
- DOI: https://doi.org/10.31857/S102872210006927-4
- ID: 120255
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全文:
详细
This work is devoted to the study of the association of MBP-hydrolyzing IgG activity with the level of antibodies to MBP in patients with schizophrenia. In the group of patients, a high level of specifi c proteolytic activity of antibodies (AT) and a twofold increase in the level of antibodies to MBP were found. A signifi cant positive correlation (r=0,48; p=0,026) was found between the studied parameters.
作者简介
D. Parshukova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
编辑信件的主要联系方式.
Junior scientist of Molecular Genetics and Biochemistry Laboratory,
Tomsk
俄罗斯联邦V. Buneva
Siberian Division of Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine
Ph D., Professor, Principal Researcher Laboratory of Reparation Enzymes,
Novosibirsk
俄罗斯联邦E. Kornetova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
Ph D., Leading Researcher Departments of endogenous disorders,
Tomsk
俄罗斯联邦D. Kazantseva
Siberian State Medical University
Student,
Tomsk
俄罗斯联邦A. Vasilevа
Siberian State Medical University
Student,
Tomsk
俄罗斯联邦S. Ivanova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
PhD, Professor, Deputy Director (Scientifi c Director) of Mental Health Research Institute,
Tomsk
俄罗斯联邦L. Smirnova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute
Email: lpsmirnova@yandex.ru
PhD, Senior Researcher of Molecular Genetics and Biochemistry Laboratory,
Tomsk
俄罗斯联邦参考
- Васильев А. Г., Чурилов Л. П., Трашков А. П., Утехин В. И. Эволюция иммунной системы и регуляторные эффекты антител. Цитология. 2018. 60 № 2.
- Невинский Г. А., Канышкова Т. Г., Семенов Д. В., Бунева В. Н. Каталитически активные антитела и их возможная биологическая функция. Вестн. РАМН 2011, № 2, 38–45.
- Лобачева О. А., Ветлугина Т. П., Семке А. В. Иммунологические критерии прогноза эффективности антипсихотической терапии больных шизофренией. Сиб. вестн. псих. и наркол. 2013, № 1 (76), 66–70.
- Клюшник Т. П., Козловская Г. В., Калинина М. А., Сарманова З. В., Отман И. Н. Динамика содержания антител к нейроантигенам в сыворотке крови больных шизофренией в процессе терапии. Журнал невр. и псих. им. С. С. Корсакова. 2008, Т. 108, № 8, 61–65.
- Parshukova D., Smirnova L. P., Ermakov E. A., Bokhan N. A., Semke A. V., Ivanova S. A., Buneva V. N., Nevinsky G. A. Autoimmunity and immune system dysregulation in schizophrenia: IgGs from sera of patients hydrolyze myelin basic protein. J Mol Recognit., 2019, 32.2: e2759.
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