ESTIMATION OF IMMUNOLOGICAL EFFICIENCY OF PEOPLE VACCINATED AGAINST ANTHRAX
- 作者: Silkina M.V.1, Kartseva A.S.1, Kalmantaeva O.V.1, Rogozin M.M.1, Firstova V.V.1, Shemyakin I.G.1
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隶属关系:
- Federal Budget Institution of Science «State Research Center for Applied Microbiology&Biotechnology» of Federal Service of Consumer Right Surveillance&Human Welfare, Ministry of Health&Welfare
- 期: 卷 22, 编号 3 (2019)
- 页面: 1274-1279
- 栏目: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119634
- DOI: https://doi.org/10.31857/S102872210007270-2
- ID: 119634
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全文:
详细
Vaccine prevention of anthrax in Russia is carried out according to epidemiological indications 1 time per year with the use of live anthrax vaccine. The main problem is the lack of a method to control the immunological efficacy of vaccination. The article presents data that analyzes the anthrax human humoral and cellular immunity among donors vaccinated 10–12 months ago with live anthrax vaccine. It was shown that in the blood serum of the most vaccinated donors did not detect antibodies to the protective antigen (PA). However, in all vaccinated patients (with the exception of one donor) T and B lymphocytes circulated in the blood enhanced proliferative activity ant the expression of activation receptors on their cell surface in response to PA in vitro. The obtained data suggested that predominantly specific cellular immunity is persisted in the long-term after vaccination against anthrax.
作者简介
M. Silkina
Federal Budget Institution of Science «State Research Center for Applied Microbiology&Biotechnology» of Federal Service of Consumer Right Surveillance&Human Welfare, Ministry of Health&Welfare
编辑信件的主要联系方式.
Email: marksil@yandex.ru
junior researcher, Laboratory of molecular biology,
Obolensk
俄罗斯联邦A. Kartseva
Federal Budget Institution of Science «State Research Center for Applied Microbiology&Biotechnology» of Federal Service of Consumer Right Surveillance&Human Welfare, Ministry of Health&Welfare
Email: fake@neicon.ru
junior researcher, Laboratory of molecular biology,
Obolensk
俄罗斯联邦O. Kalmantaeva
Federal Budget Institution of Science «State Research Center for Applied Microbiology&Biotechnology» of Federal Service of Consumer Right Surveillance&Human Welfare, Ministry of Health&Welfare
Email: fake@neicon.ru
Ph.D., researcher, Laboratory of molecular biology,
Obolensk
俄罗斯联邦M. Rogozin
Federal Budget Institution of Science «State Research Center for Applied Microbiology&Biotechnology» of Federal Service of Consumer Right Surveillance&Human Welfare, Ministry of Health&Welfare
Email: fake@neicon.ru
junior researcher, Laboratory of molecular biology,
Obolensk
俄罗斯联邦V. Firstova
Federal Budget Institution of Science «State Research Center for Applied Microbiology&Biotechnology» of Federal Service of Consumer Right Surveillance&Human Welfare, Ministry of Health&Welfare
Email: fake@neicon.ru
Doctor of Biological Sciences, Chief Researcher of the Laboratory of molecular biology,
Obolensk
俄罗斯联邦I. Shemyakin
Federal Budget Institution of Science «State Research Center for Applied Microbiology&Biotechnology» of Federal Service of Consumer Right Surveillance&Human Welfare, Ministry of Health&Welfare
Email: fake@neicon.ru
Doctor of Biological Sciences, professor, deputy director for Research,
Obolensk
俄罗斯联邦参考
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