PROPERTIES OF HUMAN NATURAL KILLER CELL SUBPOPULATIONS EXPRESSING MARKERS OF ADAPTIVE CELLS
- 作者: Kobyzeva P.A.1, Streltsova M.A.1, Erokhina S.A.1, Kovalenko E.I.1
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隶属关系:
- Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 795-797
- 栏目: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119606
- DOI: https://doi.org/10.31857/S102872210006695-9
- ID: 119606
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详细
Natural killer cells are attributed to lymphocytes of innate immunity for their ability of spontaneous antitumor activity without prior activation. However, recent studies have shown that some viral infections, such as human cytomegalovirus, can cause an increase in the number of NK cells with the phenotype CD57+NKG2C+ compared to healthy donors. It is assumed that cells of this subpopulation have some properties of adaptivity and immunological memory to HCMV infection. This paper is devoted to the study of properties of human NK-cell subpopulations selected for the markers CD57 and NKG2C, when stimulated with IL-2 and membrane-bound IL-21.
作者简介
P. Kobyzeva
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
bachelor, Laboratory of Cell Interactions,
Moscow
俄罗斯联邦M. Streltsova
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Junior Researcher of Laboratory of Cell Interactions,
Moscow
俄罗斯联邦S. Erokhina
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
PhD Student, Laboratory of Cell Interactions,
Moscow
俄罗斯联邦E. Kovalenko
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: lenkovalen@mail.ru
PhD, Senior Researcher of Laboratory of Cell Interactions,
Moscow
俄罗斯联邦参考
- Li Y., Yin J., Li T., Huang S., Yan H., Leavenworth J., Wang X. NK cell-based cancer immunotherapy: from basic biology to clinical application. Sci China Life Sci. 2015, 58(12), 1233–45.
- Peng H., Tian Z. Natural Killer Cell Memory: Progress and Implications. Front Immunol. 2017, 8, 1143.
- Goodier M.R., Jonjić S., Riley E. M., Juranić Lisnić V. CMV and natural killer cells: shaping the response to vaccination. Eur J Immunol. 2018, 48(1), 50–65.
- Kovalenko E. I., Streltsova M. A., Kanevskiy L. M., Erokhina S. A., Telford W. G. Identification of Human Memory-Like NK Cells. Curr Protoc Cytom. 2017, 79, 9.50.1–9.50.11.
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