EXPRESSION OF PLEXIN B1 BY HUMAN T LYMPHOCYTES: ROLE IN THE CONTROL OF CELL ACTIVATION
- 作者: Valieva Y.V.1, Kuklina E.M.1
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隶属关系:
- «Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences»
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 725-727
- 栏目: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119429
- DOI: https://doi.org/10.31857/S102872210006723-0
- ID: 119429
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详细
The paper presents new data on T-lymphocyte expression of plexin B1, a high-affinity receptor for class IV semaphorin Sema4D, which expression was previously attributed exclusively to non-immune cells. The biological significance of this phenomenon, as well as its role in the regulation of T-lymphocyte functions are discussed, primarily of cell migration.
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作者简介
Yu. Valieva
«Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences»
编辑信件的主要联系方式.
Email: valieva.jul.v@gmail.com
post graduate student, junior researcher, Laboratory of Immunoregulation,
Perm
俄罗斯联邦E. Kuklina
«Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences»
Email: fake@neicon.ru
Doctor of Biology, Leading Researcher, Laboratory of Immunoregulation,
Perm
俄罗斯联邦参考
- Kumanogoh A., Kikutani H. Semaphorins and their receptors: novel features of neural guidance molecules. Proc Jpn Acad Ser B Phys Biol Sci. 2010, 86, 611–620.
- Zhang Y., Liu B., Ma Y., Jin B. Sema 4D/CD100-plexin B is a multifunctional counter-receptor. Cell Mol Immunol. 2013, 10, 97–98.
- Evans E., Jonason S., Bussler H., Torno S., Veeraraghavan J., Reilly C., Doherty A., Seils J., Winter A., Mallow C., Kirk R., Howell A., Giralico S., Scrivens M., Klimatcheva K., Fisher L., Bowers J., Paris M., Smith S., and Zauderer M. Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies. Cancer Immunol. 2015, 3, 689–701.
- Hung R., Terman J. Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin fi lament disassembly. Cytoskeleton (Hoboken). 2011, 68, 415–433.
- Куклина Е. М., Некрасова И. В. Новые аспекты Sema4D-зависимого контроля активации лимфоцитов. Доклады Академии наук. 2017, 473, 1–5.
- Oinuma I., Ishikawa Y., Katoh H., and Negishi M. The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. Science. 2004, 305, 862–865.
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