THE IMPORTANCE OF GENOTYPIC AND IMMUNOPHENOTYPIC CHARACTERISTICS IN THE PATHOGENESIS AND TREATMENT OF CHRONIC HCV-INFECTION
- Authors: Nabieva U.P.1, Ismailova A.A.1, Adylov D.G.1
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Affiliations:
- Republican Scientific Center of Immunology of the Ministry of Health of the Republic of Uzbekistan
- Issue: Vol 20, No 3 (2017)
- Pages: 435-439
- Section: Articles
- URL: https://bakhtiniada.ru/1028-7221/article/view/119651
- ID: 119651
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Abstract
The article is devoted to the investigation of the correspondence of the genotype of the IL-28B gene to the virological, biochemical and immunological parameters of patients with chronic viral hepatitis C in the course of antiviral therapy of pegylated interferon α and ribavirin. It was found that with the genotype of the CC gene of the IL-28B gene at the locus rsl2979860, in which the non-genotype of the hepatitis C virus was most often detected, self-healing and high efficacy of PVT are most often observed. On the part of the organism’s reactogenicity, this was accompanied by a more pronounced cytolytic syndrome and a high immunological reactivity of the organism, manifested in an increase in the expression of cytotoxic lymphocytes CD8+, activation markers CD23+ and CD38+.
About the authors
U. P. Nabieva
Republican Scientific Center of Immunology of the Ministry of Health of the Republic of Uzbekistan
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
A. A. Ismailova
Republican Scientific Center of Immunology of the Ministry of Health of the Republic of Uzbekistan
Email: noemail@neicon.ru
Russian Federation
D. G. Adylov
Republican Scientific Center of Immunology of the Ministry of Health of the Republic of Uzbekistan
Email: noemail@neicon.ru
Russian Federation
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