Th2 TYPE CYTOKINES SYNTHESIS AND PRODUCTION AT SYSTEMIC AND LOCAL LEVEL IN PATIENTS WITH INFERTILITY AND ENDOMETRIOSIS
- Authors: Krasilnikova A.K.1, Makyshkina A.I.1, Sotnikova N.Y.1, Antziferova Y.S.1
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Affiliations:
- Federal State Budget Establishment «Ivanovo research institute of maternity and childhood by V. N. Gorodkov» of Ministry of Health of Russia
- Issue: Vol 22, No 2-2 (2019)
- Pages: 813-815
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119647
- DOI: https://doi.org/10.31857/S102872210006689-2
- ID: 119647
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Abstract
It has been established that during endometriosis, regardless of the severity of the disease, at the systemiс level IL-4 synthesis, intracellular expression of IL-4 and IL-6 were increased in the total lymphocyte and in the T-helper population, and in the peritoneal fluid the level of IL-6+ lymphocytes was increased. Changes in the synthesis, intracellular expression and the serum IL-4 content were proportional to the severity of endometriosis. In endometriosis stages I–II the intracellular production of IL-5 increased in the total lymphocyte population and in the T-helper pool. In endometriosis III–IV the IL-6 synthesis by peripheral lymphocytes increased, as well as the serum level of IL-4, the amount of IL-4+, CD4+IL-4+ lymphocytes and sCD30 in the peritoneal fluid.
About the authors
A. K. Krasilnikova
Federal State Budget Establishment «Ivanovo research institute of maternity and childhood by V. N. Gorodkov» of Ministry of Health of Russia
Author for correspondence.
Email: niimid.immune@mail.ru
Candidate of Medical Sciences, Senior Researcher of the Department of Obstetrics and Gynecology,
Russian Federation
A. I. Makyshkina
Federal State Budget Establishment «Ivanovo research institute of maternity and childhood by V. N. Gorodkov» of Ministry of Health of Russia
Email: fake@neicon.ru
Doctor of Medical sciences, professor, the director,
Ivanovo
Russian FederationN. Yu. Sotnikova
Federal State Budget Establishment «Ivanovo research institute of maternity and childhood by V. N. Gorodkov» of Ministry of Health of Russia
Email: fake@neicon.ru
Doctor of Medical sciences., professor, head of the laboratory of clinical immunology,
Ivanovo
Russian FederationYu. S. Antziferova
Federal State Budget Establishment «Ivanovo research institute of maternity and childhood by V. N. Gorodkov» of Ministry of Health of Russia
Email: fake@neicon.ru
Doctor of Biological Sciences, the leading scientific researcher of the laboratory of clinical immunology,
Ivanovo
Russian FederationReferences
- Красильникова А. К., Малышкина А. И., Сотникова Н. Ю., Анциферова Ю. С. Особенности функционального состояния фагоцитов крови у пациенток с эндометриозом I–II стадии и бесплодием. // Russian Bulletin of the obstetriciangynecologist.2017. Vol. 17. № 3. p. 9–14.
- Красильникова А. К., Абдуллаева Л. Х., Малышкина А. И., Сотникова Н. Ю., Анциферова Ю. С. Особенности регуляции гуморального иммунного ответа на системном и локальном уровнях при эндометриозе. Таврический медико-биологический вестник. 2017. Т. 20. № 2–2. С. 58–62.
- Jess T., Frisch M., Jørgensen K. T., Pedersen B. V., Nielsen N. M. Increased risk of inflammatory bowel disease in women with endometriosis: a nationwide Danish cohort study. Gut 2012;61(9):1279–83.
- Szyllo K., Tchorzewski H., Banasik M., Glowacka E., Lewkowicz P., KamerBartosinska A. The involvement of T lymphocytes in the pathogenesis of endometriotic tissues overgrowth in women with endometriosis. Mediators Inflamm. – 2003. – Vol. 12, № 3. – P. 131–138.
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