ASSESSMENT OF CD127⁻ AND CD95⁺ EXPRESSION AND GENETIC PROFILE OF WOMEN OF REPRODUCTIVE AGE EXPOSED TO PHENOL
- Authors: Dolgikh O.V.1, Kazakova O.A.1, Krivtsov A.V.1,2,3
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Affiliations:
- FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”
- FSBEI HPE “Perm State National Research University”
- FSBEI HPO “Perm State National Research Polytechnic University”
- Issue: Vol 22, No 3 (2019)
- Pages: 1125-1128
- Section: ORIGINAL ARTICLES
- URL: https://bakhtiniada.ru/1028-7221/article/view/119442
- DOI: https://doi.org/10.31857/S102872210007240-9
- ID: 119442
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Abstract
The paper presents the results of immunological and genetic blood studies of women of reproductive age living permanently under aerogenic exposure to phenol and having reproductive disorders as recurrent pregnancy loss. Immunological values – expression of T-regulatory CD127 lymphocytes and expression of CD95⁺ lymphocytes involved in apoptosis were studied. The genetic profile of women was analyzed and the polymorphic variants of genes FOXP3 T3499C rs3761547 and FAS C14405T rs1159120 participating in the expression of clusters were determined. It was found out that women having reproductive disorders and living under increased contamination of biological media with phenol have reduced level of expression of T-regulatory cells CD127 relative to healthy and unexposed women, and a lower level of CD95⁺ cells relative to the unexposed women and the norms. It results in malignant course of processes of reproductive disorders (recurrent pregnancy loss).
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About the authors
O. V. Dolgikh
FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”
Author for correspondence.
Email: oleg@fcrisk.ru
MD, Professor, Head of the Department of Immunobiological Methods of Diagnostics,
Perm
Russian FederationO. A. Kazakova
FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”
Email: fake@neicon.ru
postgraduate student, junior researcher of Immunogenetics Laboratory,
Perm
Russian FederationA. V. Krivtsov
FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies”;FSBEI HPE “Perm State National Research University”;
FSBEI HPO “Perm State National Research Polytechnic University”
Email: fake@neicon.ru
Candidate of Medical Sciences, Head of Immunogenetics Laboratory,
Perm
Russian FederationReferences
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