COMPARATIVE EVALUATION OF INDICATORS OF APOPTOSIS AND PROLIFERATION IN THE ISOLATED FRACTURE OF THE FEMORAL BONE IN CONDITIONS OF SYSTEM OZONOTHERAPY

The cytometric parameters of apoptosis and proliferation were studied in 20 men with an isolated fracture of the femur under the conditions of using systemic ozone therapy. It is shown that in case of a fracture of the femur, there is an increase in the absolute and relative number of T-lymphocytes with the expression of receptor readiness for apoptosis and the level of lymphocytes with cytometric signs of apoptosis (hypodiploid peak). The use of ozone therapy has a positive effect on the mechanisms of survival of immune cells, regardless of their phenotype, by increasing the expression of bcl-2 to the values of the control group, which can be regarded as one of the mechanisms that allow to regulate and carry out the selection of effective B-lymphocytes capable of accumulating a sufficient anti-infective antibodies in response to injury.

hip fracture, ozone therapy, apoptosis, proliferation