The Behavioral Effect of Low Dose Carbon Ions Irradiation on Mice in Short-Term Period
- Авторлар: Sorokina S.S.1, Pikalov V.A.2, Popova N.R.1
-
Мекемелер:
- Institute of Theoretical and Experimental Biophysics
- A.A. Logunov Institute of High Energy Physics
- Шығарылым: Том 70, № 1 (2025)
- Беттер: 16-20
- Бөлім: Radiation Biology
- URL: https://bakhtiniada.ru/1024-6177/article/view/361455
- DOI: https://doi.org/10.33266/1024-6177-2025-70-1-16-20
- ID: 361455
Дәйексөз келтіру
Толық мәтін
Аннотация
The active introduction of ion therapy for the treatment of oncological diseases, as well as long-term plans for the exploration of deep space, where crews will be exposed to galactic radiation, the spectrum of which is dominated by protons and high-energy ions - carbon and iron, urgently pose the task of assessing the effect of ions on cognitive functions in order to increase the effectiveness of radiotherapy and ensure the safety of space flights.
Purpose: To study the effect of a therapeutic beam of carbon ions with an energy of 450 MeV/n at the Bragg peak at a dose of 0.7 Gy on the behavior of laboratory mice in the early period after irradiation.
Material and methods: Experiments were carried out on 2-month-old male mice of the SHK (28–32 g.). Before irradiation, the animals were placed on a platform in special containers. Irradiation with a uniform beam of carbon ions with an energy of 450 MeV/n in the Bragg peak at a dose of 0.7 Gy, formed by a “wobbler” magnet, was carried out in the U-70 RBS Collective Use Center (Protvino). Two days after irradiation, the following set of methods was used to assess the general activity, spatial learning, long-term and short-term hippocampus-dependent memory of mice: “open field”, Barnes maze and a novel object recognition test.
Results: It was found that mice whole-body irradiated with a therapeutic beam of carbon ions at a dose of 0.7 Gy do not significantly exhibit an altered model of locomotor and psychoemotional behavior, but they show a deterioration in the memory trace on the 3rd day after training and a violation of episodic memory in the novel object recognition test.
Conclusion: The obtained results complement the accumulating literature data on the effects of low doses of heavy charged particles, and in particular accelerated carbon ions, on the cognitive abilities and behavior of laboratory animals, emphasizing the need to evaluate the observed effects dynamically after exposure.
Негізгі сөздер
Авторлар туралы
S. Sorokina
Institute of Theoretical and Experimental Biophysics
Email: nellipopovaran@gmail.com
Pushchino
V. Pikalov
A.A. Logunov Institute of High Energy Physics
Email: nellipopovaran@gmail.com
Protvino
N. Popova
Institute of Theoretical and Experimental Biophysics
Email: nellipopovaran@gmail.com
Pushchino
Әдебиет тізімі
- Krukowski K., Grue K., Becker M., Elizarraras E., Frias E.S., Halvorsen A., Koenig-Zanoff McK., Frattini V., Nimmagadda H., Feng X., Jones T., Nelson G., Ferguson A.R.,RosiS. The Impact of Deep Space Radiation on Cognitive Performance: From Biological Sex to Biomarkers to Countermeasures. Sci Adv. 2021;7:42:eabg6702. doi: 10.1126/sciadv.abg6702
- Cucinotta F.A., Cacao E. Predictions of Cognitive Detriments from Galactic Cosmic Ray Exposures to Astronauts on Exploration Missions. Life Sci Space Res (Amst). 2020;25:129-135. doi: 10.1016/j.lssr.2019.10.004
- Rosi S., Belarbi K., Ferguson R.A., Fishman K., Obenaus A., Raber J., Fike J.R. Trauma-Induced Alterations in Cognition and Arc Expression Are Reduced by Previous Exposure to56Fe Irradiation. Hippocampus. 2012;22:544-554. doi: 10.1002/hipo.20920
- Sorokina S.S., Malkov A.E., Shubina L.V., Zaichkina S.I., Pikalov V.A., Low Dose of Carbon Ion Irradiation Induces Early Delayed Cognitive Impairments in Mice. Radiat. Environ. Biophys. 2021;60:61–71. doi: 10.1007/s00411-020-00889-0
- Sorokina S.S., Zaichkina S.I., Rozanova O.M., Shemyakov A.E., Smirnova E.H., Dyukina A.R., Malkov A.E., Balakin V.E., Pikalov V.A. The Early Delayed Effect of Accelerated Carbon Ions and Protons on the Cognitive Functions of Mice. Biol. Bull. 2020;47: 1651–1658. doi: 10.1134/S1062359020120109
- Sorokina S.S., Pikalov V.A., Gromova D.S., Popova N.R. Cranial Irradiation of Carbon Ions Effect on the Recognition Memory in Mice. Biol. Bull. 2024;12 (In press).
- Rola R., Sarkissian V., Obenaus A., Nelson G.A., Otsuka S., Limoli C.L., Fike J.R. High-LET Radiation Induces Inflammation and Persistent Changes in Markers of Hippocampal Neurogenesis. Radiat. Res. 2005;164;4:556–560. doi: 10.1667/RR3412.1
- Liu Y., Yan J., Sun C., Li G., Li S., Zhang L., Di C., Gan L., Wang Y., Zhou R., Si J., Zhang H. Ameliorating Mitochondrial Dysfunction Restores Carbon Ion-Induced Cognitive Deficits via Co-activation of NRF2 and PINK1 Signaling Pathway. Redox Biol. 2018;17:143–157. doi: 10.1016/j.redox.2018.04.012
- Zanni G., Deutsch H., Rivera P., Shih H.-Y., LeBlancJ., Amaral,W., Lucero, M., Redfield R., DeSalle M., Chen B., Whoolery C., Reynolds R., Yun S., Eisch A. Whole-Body12C Irradiation Transiently Decreases Mouse Hippocampal Dentate Gyrus Proliferation and Immature Neuron Number, but does not Change New Neuron Survival Rate. Int. J. Mol. Sci. 2018;19:3078. doi: 10.3390/ijms19103078
- Serrano C., Dos Santos M., Kereselidze D., Beugnies L., Lestaevel P., Poirier R., Durand C. Targeted Dorsal Dentate Gyrus or Whole Brain Irradiation in Juvenile Mice Differently Affects Spatial Memory and Adult Hippocampal Neurogenesis. Biology. 2021;10;3:192. doi: 10.3390/biology10030192
- Belyaeva A.G., Shtemberg A.S., Nosovsky A.M., Vasil’eva O.N., Gordeev Yu.V., Kudrin V.S., Narkevich V.B., Krasavin E.A., Timoshenko G.N., Lapin B.A., Bazyan A.S. Effect of High-Energy Protons and12C Carbon Ions on the Cognitive Functions of Monkeys and the Content of Monoamines and their Metabolites in Peripheral Blood. Neurochemistry. 2017;34;1:1–9.
Қосымша файлдар
