Design, Synthesis, and Pharmacological Activity of a New Matrix Metalloproteinase-9 Inhibitor
- Авторлар: Grigorkevich O.S.1, Mokrov G.V.1, Dyabina A.S.1, Stolyaruk V.N.1, Tsorin I.B.1, Ionova E.O.1, Kryzhanovskii S.A.1, Gudasheva T.A.1, Durnev A.D.1
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Мекемелер:
- V. V. Zakusov Science Research Institute of Pharmacology
- Шығарылым: Том 52, № 1 (2018)
- Беттер: 30-36
- Бөлім: Search for New Drugs
- URL: https://bakhtiniada.ru/0091-150X/article/view/244977
- DOI: https://doi.org/10.1007/s11094-018-1761-1
- ID: 244977
Дәйексөз келтіру
Аннотация
The new MMP-9 inhibitor 1-{4-[(4-chlorobenzoyl)amino]phenyl}sulfonyl-L-proline, with a theoretical inhibition constant of IC50 = 4 × 105 M, was constructed on the basis of structural requirements for selective inhibitors of gelatinases. This constructed compound and its close structural analogs were synthesized and these substances were found to have low toxicity, (LD50 > 300 mg/kg). The new inhibitor given p.o. at a dose of 20 mg/kg/day on the background of acute myocardial infarction significantly decreased the content of immunoreactive MMP-9 in plasma in rats, to the level obtained with doxycycline.
Авторлар туралы
O. Grigorkevich
V. V. Zakusov Science Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Ресей, 8 Baltiiskaya Street, Moscow, 125315
G. Mokrov
V. V. Zakusov Science Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Ресей, 8 Baltiiskaya Street, Moscow, 125315
A. Dyabina
V. V. Zakusov Science Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Ресей, 8 Baltiiskaya Street, Moscow, 125315
V. Stolyaruk
V. V. Zakusov Science Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Ресей, 8 Baltiiskaya Street, Moscow, 125315
I. Tsorin
V. V. Zakusov Science Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Ресей, 8 Baltiiskaya Street, Moscow, 125315
E. Ionova
V. V. Zakusov Science Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Ресей, 8 Baltiiskaya Street, Moscow, 125315
S. Kryzhanovskii
V. V. Zakusov Science Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Ресей, 8 Baltiiskaya Street, Moscow, 125315
T. Gudasheva
V. V. Zakusov Science Research Institute of Pharmacology
Хат алмасуға жауапты Автор.
Email: tata-sosnovka@mail.ru
Ресей, 8 Baltiiskaya Street, Moscow, 125315
A. Durnev
V. V. Zakusov Science Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Ресей, 8 Baltiiskaya Street, Moscow, 125315
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